Reducing agents for synthesis

14th March 2018

Reducing Agents for Sythesis

Melrob-Eurolabs is pleased to announce an expansion to its fine chemical offering with the introduction of mini and semi bulk quantities of common organic synthesis reducing agents.

The product line includes

  • Aluminium & Sodium Hydrides
  • Borohydrides
  • Hydrazine Hydrate

All are commonplace in the organic chemist’s toolkit in virtually every organic laboratory the world over and we can supply in multi kilo quantities to help facilitate your scale up chemistry.

Our current portfolio

Borohydrides

  • Lithium Borohydride (16949-15-8)
    • Selective reduction of esters in the presence of carboxylic acids, amides and nitriles.
  • Sodium Borohydride (Granules and Powder 16940-66-2)
    • Reduction of aldehydes, ketones & acid chlorides. Use with CeCl3 for the Luche Reduction.
  • Potassium Borohydride (13762-51-1)
    • Reduction of Aldehydes, ketones and acid chlorides. Reduction of Nitroarenes to N-Arylhydroxylamines by using in conjunction with BiCl3.
  • Sodium Cyanoborohydride (25895-60-7)
    • Reduction of imines to amines. Commonly used in reductive amination.
  • Sodium Triacetoxyborohydride (56553-60-7)
    • Non aqueous reductive aminations.

Metal Hydrides

  • Sodium bis(2-methoxyethoxy)aluminumhydride (aka   Red-Al ®,  22722-98-1) 200 & 50kg
    • Extremely versatile and much safer alternative to LiAlH4. Reduction of aldehydes, ketones, carboxylic acids, esters, acyl halides and anhydrides to primary alcohols. Lactones and epoxides to diols. Amides, nitriles & imines to amines. This material is sold as a 70% solution in Toluene.
  • Sodium Hydride (7646-69-7)
    • For Diborane generation with BF3, also Disilane and Disulfide reduction. Sold as min 57% dispersion in mineral oil.

Hydrazine

  • Hydrazine Hydrate (7803-57-8)
    • Wolff-Kischner reduction of ketones to methylenes.

Additional Reagents

  • Cerium Chloride Heptahydrate (18618-55-8)
    • For Luche reduction of alpha,beta-unsaturated carbonyl compounds.

Click here for details of pack sizes and a downloadable pdf

We hope these will act as a useful additional offering to our traditional organic intermediates portfolio, allowing our clients to access scale up quantities of these important reagents for their kilo lab and pilot plant projects.

Dr Graham Oakes

For more information or to request a quotation please contact us at: enquiries@melrob.com